Fullerene Cā‚†ā‚€ Derivatives Attenuated Microglia-Mediated Prion Peptide Neurotoxicity

Created on 2022-09-03T10:34:46-05:00

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Variants of C60 (C60-OH, and C60-NH2) found to reduce inflammation markers.

Take together, these results suggest that C60-OH protects neuronal cells against PrP(106-126)-mediated neurotoxicity through activation of Nrf2 pathway, and provides evidence that fullerene derivatives may have therapeutic potential in prion diseases.