Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells

Created on 2021-08-07T02:00:33-05:00

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hot aqueous and ethanolic extracts and crude polysaccharides on rat pheochromocytoma (PC-12) cells were studied
the hot aqueous extract exhibited neuritogenic activity comparable to NGF in PC-12 cells.
However, the extracts and crude polysaccharides stimulated neuritogenesis without stimulating the production of NGF in PC-12 cells.
The neuritogenic activity in PC-12 cells stimulated by hot aqueous and ethanolic extracts and crude polysaccharides of L. rhinocerotis sclerotium mimicking NGF activity via the MEK/ERK1/2 signaling pathway is reported for the first time.