Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes

Created on 2021-08-06T23:58:56-05:00

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diabetes-induced retinal neurodegeneration positively correlates with oxidative stress and peroxynitrite.
Studies also show that peroxynitrite impairs nerve growth factor (NGF) survival signaling in sensory neurons.
FeTPPS prevented tyrosine nitration, restored NGF survival signal, and prevented neuronal death in vitro and in vivo.
Together, these data suggest that diabetes-induced peroxynitrite impairs NGF neuronal survival by nitrating TrkA receptor and enhancing p75NTR expression.